Compounds > 2-[[[2-methyl-1-(phenylmethyl)-5-benzimidazolyl]amino]methyl]phenol
Page last updated: 2024-09-27

2-[[[2-methyl-1-(phenylmethyl)-5-benzimidazolyl]amino]methyl]phenol

Cross-References

ID SourceID
PubMed CID563543
CHEMBL ID486094
CHEBI ID105755

Synonyms (19)

Synonym
OPREA1_480223
MLS000703372
smr000273836
OPREA1_737995
CHEMDIV2_002216
2-{[(1-benzyl-2-methyl-1h-benzimidazol-5-yl)amino]methyl}phenol
STK071628
CHEBI:105755
HMS1375E16
AKOS000673691
2-[[(1-benzyl-2-methylbenzimidazol-5-yl)amino]methyl]phenol
CHEMBL486094
HMS2661I12
DNRQRIUQDVKUPF-UHFFFAOYSA-N
2-([(1-benzyl-2-methyl-1h-benzimidazol-5-yl)amino]methyl)phenol #
phenol, 2-(1-benzyl-2-methyl-5-benzimidazolylaminomethyl)-
Q27183527
2-[[[2-methyl-1-(phenylmethyl)-5-benzimidazolyl]amino]methyl]phenol
2-{[(1-benzyl-2-methyl-1h-1,3-benzodiazol-5-yl)amino]methyl}phenol

Drug Classes (1)

ClassDescription
benzimidazolesAn organic heterocyclic compound containing a benzene ring fused to an imidazole ring.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (19)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency6.30960.004023.8416100.0000AID485290
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency31.62280.631035.7641100.0000AID504339
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency39.81070.177814.390939.8107AID2147
LuciferasePhotinus pyralis (common eastern firefly)Potency23.93410.007215.758889.3584AID588342
ATAD5 protein, partialHomo sapiens (human)Potency16.35350.004110.890331.5287AID504467
TDP1 proteinHomo sapiens (human)Potency24.84460.000811.382244.6684AID686978; AID686979
Microtubule-associated protein tauHomo sapiens (human)Potency44.66840.180013.557439.8107AID1460
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency39.81070.011212.4002100.0000AID1030
regulator of G-protein signaling 4Homo sapiens (human)Potency56.23410.531815.435837.6858AID504845
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency19.95260.707936.904389.1251AID504333
lysosomal alpha-glucosidase preproproteinHomo sapiens (human)Potency39.50680.036619.637650.1187AID2100
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency79.43280.354828.065989.1251AID504847
chromobox protein homolog 1Homo sapiens (human)Potency17.78280.006026.168889.1251AID540317
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency35.48133.548119.542744.6684AID743266
pyruvate kinase PKM isoform aHomo sapiens (human)Potency5.01190.04017.459031.6228AID1631; AID1634
serine/threonine-protein kinase PLK1Homo sapiens (human)Potency3.35870.168316.404067.0158AID720504
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1Homo sapiens (human)Potency23.93410.425612.059128.1838AID504891
DNA polymerase iota isoform a (long)Homo sapiens (human)Potency63.09570.050127.073689.1251AID588590
nuclear receptor ROR-gamma isoform 1Mus musculus (house mouse)Potency17.90080.00798.23321,122.0200AID2546; AID2551
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID404521Cytotoxicity against human SKBR3 cells at 10 uM after 72 hrs by MTT assay2008Journal of medicinal chemistry, Jun-26, Volume: 51, Issue:12
Discovery of novel small-molecule inhibitors of human epidermal growth factor receptor-2: combined ligand and target-based approach.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's3 (50.00)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
lapatinib[no description available]medium10furans;
organochlorine compound;
organofluorine compound;
quinazolines		antineoplastic agent;
tyrosine kinase inhibitor
N-[2-(2-fluorophenyl)ethyl]-5,6,7,8-tetrahydro-[1,2,4]triazolo[5,1-b]quinazolin-9-amine[no description available]medium10quinazolines
cp 724714[no description available]medium102-methoxy-N-[3-[4-[3-methyl-4-[(6-methyl-3-pyridinyl)oxy]anilino]-6-quinazolinyl]prop-2-enyl]acetamideantineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor;
hepatotoxic agent
albendazole[no description available]low00aryl sulfide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		anthelminthic drug;
microtubule-destabilising agent;
tubulin modulator
astemizole[no description available]low00benzimidazoles;
piperidines		anti-allergic agent;
anticoronaviral agent;
H1-receptor antagonist
cgp 12177[no description available]low00aromatic ether;
benzimidazoles;
secondary alcohol;
secondary amino compound		beta-adrenergic antagonist
clemizole[no description available]low00benzimidazoles;
monochlorobenzenes;
pyrrolidines		histamine antagonist
domperidone[no description available]low00benzimidazoles;
heteroarylpiperidine		antiemetic;
dopaminergic antagonist
droperidol[no description available]low00aromatic ketone;
benzimidazoles;
organofluorine compound		anaesthesia adjuvant;
antiemetic;
dopaminergic antagonist;
first generation antipsychotic
emedastine[no description available]low00benzimidazolesanti-allergic agent;
antipruritic drug;
H1-receptor antagonist
fenbendazole[no description available]low00aryl sulfide;
benzimidazoles;
carbamate ester		antinematodal drug
lansoprazole[no description available]low00benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
mebendazole[no description available]low00aromatic ketone;
benzimidazoles;
carbamate ester		antinematodal drug;
microtubule-destabilising agent;
tubulin modulator
nocodazole[no description available]low00aromatic ketone;
benzimidazoles;
carbamate ester;
thiophenes		antimitotic;
antineoplastic agent;
microtubule-destabilising agent;
tubulin modulator
ns 1619[no description available]low00(trifluoromethyl)benzenes;
benzimidazoles;
phenols		potassium channel opener
omeprazole[no description available]low00aromatic ether;
benzimidazoles;
pyridines;
sulfoxide
oxatomide[no description available]low00benzimidazoles;
diarylmethane;
N-alkylpiperazine		anti-allergic agent;
anti-inflammatory agent;
geroprotector;
H1-receptor antagonist;
serotonergic antagonist
oxibendazole[no description available]low00benzimidazoles;
carbamate ester
pantoprazole[no description available]low00aromatic ether;
benzimidazoles;
organofluorine compound;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor;
environmental contaminant;
xenobiotic
pimobendan[no description available]low00benzimidazoles;
pyridazinone		cardiotonic drug;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent
rabeprazole[no description available]low00benzimidazoles;
pyridines;
sulfoxide		anti-ulcer drug;
EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor
thiabendazole[no description available]low001,3-thiazoles;
benzimidazole fungicide;
benzimidazoles		antifungal agrochemical;
antinematodal drug
2-methylbenzimidazole[no description available]low00benzimidazoles
bendazole[no description available]low00benzimidazoles
2-aminobenzimidazole[no description available]low00benzimidazolesmarine xenobiotic metabolite
pimozide[no description available]low00benzimidazoles;
heteroarylpiperidine;
organofluorine compound		antidyskinesia agent;
dopaminergic antagonist;
first generation antipsychotic;
H1-receptor antagonist;
serotonergic antagonist
fuberidazole[no description available]low00benzimidazole fungicide;
benzimidazoles;
furans		antifungal agrochemical
2-Butyl-1H-benzimidazole[no description available]low00benzimidazoles
lobendazole[no description available]low00benzimidazoles;
carbamate ester
carbendazim[no description available]low00benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		antifungal agrochemical;
antinematodal drug;
metabolite;
microtubule-destabilising agent
parbendazole[no description available]low00benzimidazoles;
carbamate ester
benomyl[no description available]low00aromatic amide;
benzimidazole fungicide;
benzimidazoles;
benzimidazolylcarbamate fungicide;
carbamate ester		acaricide;
anthelminthic drug;
antifungal agrochemical;
microtubule-destabilising agent;
tubulin modulator
ensulizole[no description available]low00benzimidazoles
flubendazole[no description available]low00aromatic ketone;
benzimidazoles;
carbamate ester;
organofluorine compound		antinematodal drug;
teratogenic agent
ciclobendazole[no description available]low00benzimidazoles;
carbamate ester
oxfendazole[no description available]low00benzimidazoles;
carbamate ester;
sulfoxide		antinematodal drug
liarozole[no description available]low00benzimidazoles
bendamustine[no description available]low00benzimidazoles
propazole[no description available]low00benzimidazoles
mizolastine[no description available]low00benzimidazoles
cgs 9343b[no description available]low00benzimidazoles
telmisartan[no description available]low00benzimidazoles;
biphenyls;
carboxybiphenyl		angiotensin receptor antagonist;
antihypertensive agent;
EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor;
environmental contaminant;
xenobiotic
chlormidazole[no description available]low00benzimidazoles
2-amino-1-methylbenzimidazole[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-yl)aniline[no description available]low00benzimidazoles;
primary arylamine;
substituted aniline		geroprotector
5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one[no description available]low00benzimidazoles
5-hydroxythiabendazole[no description available]low00benzimidazoles
5-hydroxymethylomeprazole[no description available]low00aromatic ether;
benzimidazoles;
pyridines;
sulfoxide		drug metabolite
omeprazole magnesium[no description available]low00benzimidazoles;
sulfoxide
omeprazole sulfone[no description available]low00benzimidazoles;
sulfoxide
omeprazole sulfide[no description available]low00benzimidazoles
desmethylastemizole[no description available]low00benzimidazoles
bilastine[no description available]low00benzimidazoles
dabigatran etexilate[no description available]low00aromatic amide;
benzimidazoles;
beta-alanine derivative;
carboxamidine;
carboxylic ester;
pyridines		anticoagulant;
EC 3.4.21.5 (thrombin) inhibitor;
prodrug
ilaprazole[no description available]low00benzimidazoles;
sulfoxide
dabigatran[no description available]low00aromatic amide;
benzimidazoles;
beta-alanine derivative;
carboxamidine;
pyridines		anticoagulant;
EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor;
EC 3.4.21.5 (thrombin) inhibitor
N-butyl-1H-benzimidazol-2-amine[no description available]low00benzimidazoles
3,4-dihydro-2H-benzo[4,5]imidazo[2,1-b][1,3]thiazin-3-ol[no description available]low00benzimidazoles
1-methyl-3-phenylpyrazino[1,2-a]benzimidazole[no description available]low00benzimidazoles
2-methyl-1H-pyrimido[1,2-a]benzimidazol-4-one[no description available]low00benzimidazoles
6-methyl-2-[(4-nitrophenyl)methylthio]-1H-benzimidazole[no description available]low00benzimidazoles
1-(phenylmethyl)benzimidazole[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-ylthio)-1-thiophen-2-ylethanone[no description available]low00benzimidazoles
2-(2-phenoxyethylsulfonyl)-1H-benzimidazole[no description available]low00benzimidazoles;
sulfoxide
2-[[(6-bromo-1H-benzimidazol-2-yl)thio]methyl]-1-methylbenzimidazole[no description available]low00benzimidazoles
4-oxo-10H-pyrimido[1,2-a]benzimidazole-3-carboxylic acid ethyl ester[no description available]low00benzimidazoles
2-[[5-[2-(1H-benzimidazol-2-yl)ethyl]-4-methyl-1,2,4-triazol-3-yl]thio]-N-(5-methyl-1,3,4-thiadiazol-2-yl)acetamide[no description available]low00benzimidazoles
LSM-19079[no description available]low00benzimidazoles
1-(1-benzimidazolyl)-3-(1-cyclohex-3-enylmethoxy)-2-propanol[no description available]low00benzimidazoles
N-(3H-benzimidazol-5-yl)-2-furancarboxamide[no description available]low00benzimidazoles
2-[[3-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]acetic acid methyl ester[no description available]low00benzimidazoles
N-[1-[(4-methylphenyl)methyl]-2-benzimidazolyl]-2-furancarboxamide[no description available]low00benzimidazoles
11-[2-(4-morpholinyl)ethylamino]-7,8,9,10-tetrahydrobenzimidazolo[1,2-b]isoquinoline-6-carbonitrile[no description available]low00benzimidazoles
2-(1-benzimidazolylmethyl)-5-[(4-chlorophenyl)methylthio]-1,3,4-oxadiazole[no description available]low00benzimidazoles
N-[2-(3-acetamidophenyl)-3H-benzimidazol-5-yl]acetamide[no description available]low00benzimidazoles
N-[1-[2-(2-chlorophenoxy)ethyl]-2-benzimidazolyl]acetamide[no description available]low00benzimidazoles
N-[1-(2-methoxyphenyl)-5-benzimidazolyl]benzenesulfonamide[no description available]low00benzimidazoles
2-[2-(ethylthio)-1-benzimidazolyl]-1-(1-piperidinyl)ethanone[no description available]low00benzimidazoles
2-[[5-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(5-methyl-3-isoxazolyl)acetamide[no description available]low00benzimidazoles
2-(beta-D-glucosyl)benzimidazole[no description available]low00benzimidazoles;
C-glycosyl compound
N-[1-(1-hexyl-2-benzimidazolyl)ethyl]-2-furancarboxamide[no description available]low00benzimidazoles
2-ethyl-1-[(2-methoxyphenyl)methyl]benzimidazole[no description available]low00benzimidazoles
2-(4-methoxyphenyl)-1-(2-methylprop-2-enyl)benzimidazole[no description available]low00benzimidazoles
2-[[(1-propan-2-yl-2-benzimidazolyl)amino]methyl]-6-prop-2-enylphenol[no description available]low00benzimidazoles
4-(1H-benzimidazol-2-ylmethylthio)-2-methylbenzofuro[3,2-d]pyrimidine[no description available]low00benzimidazoles
N-(3,4-dihydro-1H-[1,4]thiazino[4,3-a]benzimidazol-8-yl)pentanamide[no description available]low00benzimidazoles
N-(3,4-dihydro-1H-[1,4]thiazino[4,3-a]benzimidazol-8-yl)butanamide[no description available]low00benzimidazoles
N-[2-(2-benzamidoethyl)-1-methyl-5-benzimidazolyl]-2-furancarboxamide[no description available]low00benzimidazoles
3-(1-benzimidazolylmethyl)-6-[(4-methoxyphenoxy)methyl]-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole[no description available]low00benzimidazoles;
triazolothiadiazole
2-methoxy-1-(1-methyl-2-benzimidazolyl)-1-phenylethanamine[no description available]low00benzimidazoles
N2-(1H-benzimidazol-2-yl)benzene-1,2-diamine[no description available]low00benzimidazoles
2-[(2-ethoxy-2-oxoethyl)thio]-1-benzimidazolecarboxylic acid ethyl ester[no description available]low00benzimidazoles
6-methyl-2-(trifluoromethyl)-3,5-dihydroimidazo[4,5-f]benzimidazole[no description available]low00benzimidazoles
3,4-dimethyl-N-[[(2-oxo-1,3-dihydrobenzimidazol-5-yl)amino]-sulfanylidenemethyl]benzamide[no description available]low00benzimidazoles
4-[1-[(3-methoxy-4-methylphenyl)methyl]-2-benzimidazolyl]-1,2,5-oxadiazol-3-amine[no description available]low00benzimidazoles
1-ethyl-2-[[(1-methyl-2-benzimidazolyl)thio]methyl]benzimidazole[no description available]low00benzimidazoles
2,6-bis(benzimidazol-2-yl)pyridine[no description available]low00benzimidazoles
N,N,2-trimethyl-1-phenyl-5-benzimidazolesulfonamide[no description available]low00benzimidazoles
4-[2-(1-methyl-2-benzimidazolyl)ethyl]aniline[no description available]low00benzimidazoles
5,6-dimethyl-2-[2-(1-pyrrolidinyl)ethylthio]-1H-benzimidazole[no description available]low00benzimidazoles
2-[(2-methoxyphenoxy)methyl]-1H-benzimidazole[no description available]low00benzimidazoles
4-(1-ethyl-2-benzimidazolyl)aniline[no description available]low00benzimidazoles
3-(2-phenoxyethyl)-1H-benzimidazole-2-thione[no description available]low00benzimidazoles
N-[1-(4-methylphenyl)-5-benzimidazolyl]acetamide[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-ylthio)-N-(5-propyl-1,3,4-thiadiazol-2-yl)acetamide[no description available]low00benzimidazoles
4-[(1H-benzimidazol-2-ylthio)methyl]-2-thiazolamine[no description available]low00benzimidazoles
3-[2-(4-methyl-2-propan-2-ylphenoxy)ethyl]-1H-benzimidazole-2-thione[no description available]low00benzimidazoles
4-methyl-N-[1-[2-(1-pyrrolidinyl)ethyl]-2-benzimidazolyl]benzamide[no description available]low00benzimidazoles
1-ethyl-2-[(4-methylphenoxy)methyl]benzimidazole[no description available]low00benzimidazoles
2-(2,5-dimethylphenyl)-3H-benzimidazol-5-amine[no description available]low00benzimidazoles
(2'-(4-aminophenyl)-(2,5'-bi-1h-benzimidazol)-5-amine)[no description available]low00benzimidazoles
N-(2-furanylmethyl)-1-(4-methoxyphenyl)-5-benzimidazolamine[no description available]low00benzimidazoles
N-(1-propyl-5-benzimidazolyl)-2-thiophenecarboxamide[no description available]low00benzimidazoles
N-(1-tert-butyl-5-benzimidazolyl)-2-thiophenecarboxamide[no description available]low00benzimidazoles
2-(3-methyl-2-oxo-1-benzimidazolyl)acetonitrile[no description available]low00benzimidazoles
6-(1H-benzimidazol-2-yl)-2-methyl-1H-benzimidazole[no description available]low00benzimidazoles
1-[2-(2-chlorophenoxy)ethyl]benzimidazole[no description available]low00benzimidazoles
1-ethyl-N-[(4-methoxyphenyl)methyl]-5-benzimidazolamine[no description available]low00benzimidazoles
5-(1-methyl-2-benzimidazolyl)-2-thiophenecarboxaldehyde[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-ylmethyl)benzene-1,4-diol[no description available]low00benzimidazoles
1-[(3-methylphenyl)methyl]benzimidazole[no description available]low00benzimidazoles
1-(2-methylpropyl)-2-thiophen-2-ylbenzimidazole[no description available]low00benzimidazoles
N-(1,3-dimethyl-2-oxo-5-benzimidazolyl)-2-benzofurancarboxamide[no description available]low00benzimidazoles
N-(2-ethoxyphenyl)-1H-benzimidazol-2-amine[no description available]low00benzimidazoles
N-cycloheptyl-2-[(6-nitro-1H-benzimidazol-2-yl)thio]acetamide[no description available]low00benzimidazoles
2-methyl-N-[2-[1-[2-(4-methylphenoxy)ethyl]-2-benzimidazolyl]ethyl]propanamide[no description available]low00benzimidazoles
N-(1-tert-butyl-5-benzimidazolyl)-3,4,5-trimethoxybenzamide[no description available]low00benzimidazoles
N-[2-(2-pyridinyl)-3H-benzimidazol-5-yl]cyclohexanecarboxamide[no description available]low00benzimidazoles
N-[2-(3-pyridinyl)-3H-benzimidazol-5-yl]-2-furancarboxamide[no description available]low00benzimidazoles
1-(4-morpholinyl)-2-[2-(phenylmethylthio)-1-benzimidazolyl]ethanone[no description available]low00benzimidazoles
2-ethyl-N-[1-[2-(1-piperidinyl)ethyl]-2-benzimidazolyl]-3-pyrazolecarboxamide[no description available]low00benzimidazoles
4-[[2-(phenylmethyl)-1-benzimidazolyl]sulfonyl]morpholine[no description available]low00benzimidazoles
N-[2-(1H-benzimidazol-2-yl)ethyl]-2-(2-bromophenoxy)acetamide[no description available]low00benzimidazoles
N-[(3-methoxyphenyl)methyl]-1-propyl-5-benzimidazolamine[no description available]low00benzimidazoles
5-(2,3-dihydroindol-1-ylsulfonyl)-1,3-diethyl-2-benzimidazolone[no description available]low00benzimidazoles
N-(2-fluorophenyl)-2-[2-(4-thiazolyl)-1-benzimidazolyl]acetamide[no description available]low00benzimidazoles
N-[[4-(diethylamino)phenyl]methyl]-1-[2-(1-piperidinyl)ethyl]-2-benzimidazolamine[no description available]low00benzimidazoles
N-[[5-(1H-benzimidazol-2-yl)-2-methylanilino]-sulfanylidenemethyl]-5-chloro-2-methoxybenzamide[no description available]low00benzimidazoles
5,6-dimethyl-2-[1-[[1-(phenylmethyl)-5-tetrazolyl]methyl]-4-piperidinyl]-1H-benzimidazole[no description available]low00benzimidazoles
2-[[5-(1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(5-ethyl-1,3,4-thiadiazol-2-yl)acetamide[no description available]low00benzimidazoles
2-[[[5-(5,6-dimethyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]methyl]benzonitrile[no description available]low00benzimidazoles
2-(2-chloro-3-pyridinyl)-1-prop-2-enylbenzimidazole[no description available]low00benzimidazoles
6-(4-methyl-1-piperazinyl)-2-(3,4,5-trimethoxyphenyl)-1H-benzimidazole[no description available]low00benzimidazoles
2-(6-chloro-3-pyridinyl)-1H-benzimidazole[no description available]low00benzimidazoles
4-[1-[(3-methoxyphenyl)methyl]-2-benzimidazolyl]-1,2,5-oxadiazol-3-amine[no description available]low00benzimidazoles
11-[2-(diethylamino)ethylamino]-7,8,9,10-tetrahydrobenzimidazolo[1,2-b]isoquinoline-6-carbonitrile[no description available]low00benzimidazoles
N-[2-(1H-benzimidazol-2-yl)ethyl]-3,5-dinitrobenzamide[no description available]low00benzimidazoles
2-[[2-(2-methylphenoxy)ethylthio]methyl]-1H-benzimidazole[no description available]low00benzimidazoles
N-[[5-(1H-benzimidazol-2-yl)-2-chloroanilino]-sulfanylidenemethyl]-2,6-dimethoxybenzamide[no description available]low00benzimidazoles
3-(1H-benzimidazol-2-yl)-N-(3-pyridinylmethyl)aniline[no description available]low00benzimidazoles
3-[3-[[2-oxo-2-(1,2,5-trimethyl-3-pyrrolyl)ethyl]thio]propyl]-1H-benzimidazol-2-one[no description available]low00benzimidazoles
2-[[6-(butylsulfamoyl)-1H-benzimidazol-2-yl]thio]-N-(2-chlorophenyl)acetamide[no description available]low00benzimidazoles
1-[4-(1H-benzimidazol-2-yl)phenyl]-3-[3-(4-morpholinyl)propyl]thiourea[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-ylthio)-1-(2,5-dimethyl-1-prop-2-enyl-3-pyrrolyl)ethanone[no description available]low00benzimidazoles
N-[4-(1H-benzimidazol-2-yl)phenyl]-2,3,4,5,6-pentafluorobenzamide[no description available]low00benzimidazoles
N-[2-[5-(1,3-benzothiazol-2-yl)-3-ethyl-1-phenyl-2-benzimidazol-3-iumyl]ethenyl]-N-methylaniline[no description available]low00benzimidazoles
1-(2-chlorophenyl)-3-[[(1-ethyl-2-methyl-5-benzimidazolyl)-oxomethyl]amino]thiourea[no description available]low00benzimidazoles
1-[[2-(1H-benzimidazol-2-ylthio)-1-oxoethyl]amino]-3-ethylthiourea[no description available]low00benzimidazoles
2-[(6-methyl-1H-benzimidazol-2-yl)thio]-1-(2-methyl-1H-indol-3-yl)ethanone[no description available]low00benzimidazoles
2-[(6-chloro-1H-benzimidazol-2-yl)thio]-N-(2,3-dihydro-1H-inden-5-yl)acetamide[no description available]low00benzimidazoles
N-(1H-benzimidazol-2-yl)-4-(3-methylphenoxy)butanamide[no description available]low00benzimidazoles
N-(1H-benzimidazol-2-yl)-2-methylsulfonylbenzamide[no description available]low00benzimidazoles
1H-benzimidazole-5,6-diamine[no description available]low00benzimidazoles
N-(4-methylphenyl)-5-nitro-4-spiro[benzimidazole-2,1'-cyclohexane]amine[no description available]low00benzimidazoles
1-(2-chlorophenoxy)-3-(2-methyl-1-benzimidazolyl)-2-propanol[no description available]low00benzimidazoles
2-phenyl-2,3-dihydro-[1,3]thiazino[3,2-a]benzimidazol-4-one[no description available]low00benzimidazoles
2-[[(1-butyl-2-benzimidazolyl)amino]methyl]phenol[no description available]low00benzimidazoles
2,2'-[3-(2-methoxyphenyl)-1,2-propanediyl]bis(1H-benzimidazole)[no description available]low00benzimidazoles
N-(1-butyl-2-benzimidazolyl)cyclohexanecarboxamide[no description available]low00benzimidazoles
1-azepanyl-[2-(phenylmethyl)-1-benzimidazolyl]methanone[no description available]low00benzimidazoles
[1-[3-(4-methylphenoxy)propyl]-2-benzimidazolyl]methanol[no description available]low00benzimidazoles
1-(2-methoxyethyl)-2-[(4-methoxyphenoxy)methyl]benzimidazole[no description available]low00benzimidazoles
4H-[1,3]thiazino[3,2-a]benzimidazol-4-ol[no description available]low00benzimidazoles
3-[5-(dimethylsulfamoyl)-1-ethyl-2-benzimidazolyl]-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-yl)propanamide[no description available]low00benzimidazoles
N-(1,1-dioxo-3-thiolanyl)-N-methyl-2-[[1-(2-phenylethyl)-2-benzimidazolyl]thio]acetamide[no description available]low00benzimidazoles
7-[[[1-(3-methylphenyl)-2-benzimidazolyl]thio]methyl]-5-thiazolo[3,2-a]pyrimidinone[no description available]low00benzimidazoles
2-(4-cyanophenoxy)-N-(2-methyl-1-phenyl-5-benzimidazolyl)acetamide[no description available]low00benzimidazoles
5-hydroxybenzimidazole[no description available]low00benzimidazoles;
phenols		bacterial metabolite;
human metabolite;
rat metabolite
2-[8-(6-amino-1H-benzimidazol-2-yl)octyl]-3H-benzimidazol-5-amine[no description available]low00benzimidazoles
2-(2,3,3-trichloro-1-nitroprop-2-enylidene)-1,3-dihydrobenzimidazole[no description available]low00benzimidazoles
N-[4-(1H-benzimidazol-2-yl)phenyl]-4-ethoxy-3-nitrobenzamide[no description available]low00benzimidazoles
N-[4-(1H-benzimidazol-2-yl)phenyl]-2-methyl-4-nitro-3-pyrazolecarboxamide[no description available]low00benzimidazoles
N-[2-[1-methyl-5-[[(4-methylphenyl)-oxomethyl]amino]-2-benzimidazolyl]ethyl]-2-furancarboxamide[no description available]low00benzimidazoles
2-[[5-[2-(1H-benzimidazol-2-yl)ethyl]-4-methyl-1,2,4-triazol-3-yl]thio]acetonitrile[no description available]low00benzimidazoles
1-cyclopentyl-1-[2-(5,6-dimethyl-1H-benzimidazol-2-yl)ethyl]-3-(2-oxolanylmethyl)thiourea[no description available]low00benzimidazoles
2-[[5-(6-methyl-1H-benzimidazol-2-yl)-2-pyridinyl]thio]-N-(4-methyl-2-thiazolyl)acetamide[no description available]low00benzimidazoles
1-(2-methoxyethyl)-2-[(4-methylphenoxy)methyl]benzimidazole[no description available]low00benzimidazoles
3,4,5-trimethoxy-N-[2-(1-methyl-2-benzimidazolyl)ethyl]benzamide[no description available]low00benzimidazoles
1-(2,4-difluorophenyl)-2-methyl-N-[2-(4-morpholinyl)ethyl]-5-benzimidazolecarboxamide[no description available]low00benzimidazoles
[1-(3-methylphenyl)-5-benzimidazolyl]-(1-piperidinyl)methanone[no description available]low00benzimidazoles
2-[(1-acetyl-2-benzimidazolyl)thio]-N-(2-methoxyphenyl)acetamide[no description available]low00benzimidazoles
N-[[4-(dimethylamino)phenyl]methyl]-1-ethyl-5-benzimidazolamine[no description available]low00benzimidazoles
2-[(4-cyano-1-oxo-5H-pyrido[1,2-a]benzimidazol-3-yl)methylthio]propanoic acid[no description available]low00benzimidazoles
2-[2-(2-chlorophenyl)-1-benzimidazolyl]-N-(2-propan-2-ylphenyl)acetamide[no description available]low00benzimidazoles
N,N,1-triethyl-2-sulfanylidene-3H-benzimidazole-5-sulfonamide[no description available]low00benzimidazoles
2-methyl-1-phenyl-5-benzimidazolecarboxylic acid [2-(2-methoxyanilino)-2-oxoethyl] ester[no description available]low00benzimidazoles
3-[5-(dimethylsulfamoyl)-1-ethyl-2-benzimidazolyl]propanoic acid[no description available]low00benzimidazoles
1-ethyl-3-[[2-[(1-methyl-2-benzimidazolyl)thio]-1-oxoethyl]amino]thiourea[no description available]low00benzimidazoles
6-nitro-3-phenyl-1H-benzimidazole-2-thione[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-yl)-5-methyl-4-(phenylmethyl)-4H-pyrazol-3-one[no description available]low00benzimidazoles
2-(1H-benzimidazol-2-ylthio)-1-[2,5-dimethyl-1-(2-oxolanylmethyl)-3-pyrrolyl]ethanone[no description available]low00benzimidazoles
N-[2-(4-fluorophenyl)ethyl]-2-[2-(2-hydroxyethylamino)-1-benzimidazolyl]acetamide[no description available]low00benzimidazoles
N-(3,5-dichloro-2-pyridinyl)-2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]propanamide[no description available]low00benzimidazoles
N-(5-chloro-2-pyridinyl)-2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]acetamide[no description available]low00benzimidazoles
1-(1H-benzimidazol-2-yl)-3-cyclohexylurea[no description available]low00benzimidazoles
2-[(2,2-dichloro-3,3-dimethylcyclopropyl)methylthio]-1H-benzimidazole[no description available]low00benzimidazoles
N-[4-(1H-benzimidazol-2-yl)phenyl]-3-(2,5-dioxo-1-pyrrolidinyl)benzamide[no description available]low00benzimidazoles
N-(3,5-dichloro-2-pyridinyl)-2-[(1-phenyl-2-benzimidazolyl)thio]acetamide[no description available]low00benzimidazoles
2-[2-(2-chlorophenyl)-1-benzimidazolyl]-N-(2,6-diethylphenyl)acetamide[no description available]low00benzimidazoles
N-[1-(1H-benzimidazol-2-yl)-3-(methylthio)propyl]-3,5-dinitrobenzamide[no description available]low00benzimidazoles
N-(1H-benzimidazol-2-yl)-3-phenylbutanamide[no description available]low00benzimidazoles
4-[2-[[1-(2-methoxyethyl)-2-benzimidazolyl]thio]-1-oxoethyl]-2,5-dimethyl-1H-pyrrole-3-carboxylic acid ethyl ester[no description available]low00benzimidazoles
1-(4-ethylphenyl)-2-methyl-N-(3-pyridinylmethyl)-5-benzimidazolecarboxamide[no description available]low00benzimidazoles
2-methyl-1-phenyl-5-benzimidazolecarboxylic acid [2-(3-methylbutan-2-ylamino)-2-oxoethyl] ester[no description available]low00benzimidazoles
N-[1-[1-[2-[4-(diethylamino)anilino]-2-oxoethyl]-2-benzimidazolyl]ethyl]-4-methylbenzamide[no description available]low00benzimidazoles
N-(1H-benzimidazol-2-yl)-2-nitrobenzamide[no description available]low00benzimidazoles
N-(1H-benzimidazol-2-yl)-3-(1-imidazolyl)propanamide[no description available]low00benzimidazoles
N-[6-amino-2,4-dioxo-1-(phenylmethyl)-5-pyrimidinyl]-2-[(1-ethyl-2-benzimidazolyl)thio]-N-methylacetamide[no description available]low00benzimidazoles
N-[[1-(2-phenoxyethyl)-2-benzimidazolyl]methyl]aniline[no description available]low00benzimidazoles
N-[2-(2-benzamidoethyl)-1-methyl-5-benzimidazolyl]-2-methoxybenzamide[no description available]low00benzimidazoles
3-[5-(diethylsulfamoyl)-1-methyl-2-benzimidazolyl]propanoic acid [2-(3,5-dichloroanilino)-2-oxoethyl] ester[no description available]low00benzimidazoles
3-[1-butyl-5-(diethylsulfamoyl)-2-benzimidazolyl]propanoic acid[no description available]low00benzimidazoles
1-cyclohexyl-N-(3-methylbutyl)-5-benzimidazolecarboxamide[no description available]low00benzimidazoles
5,6-dimethyl-1-octyl-4-benzimidazolamine[no description available]low00benzimidazoles
2-[(6-chloro-2-phenyl-1-benzimidazolyl)oxy]acetic acid[no description available]low00benzimidazoles
esomeprazole magnesium[no description available]low00benzimidazoles;
sulfoxide
methiazole[no description available]low00benzimidazoles;
carbamate ester
flibanserin[no description available]low00benzimidazoles;
N-alkylpiperazine;
N-arylpiperazine;
organofluorine compound		antidepressant;
serotonergic agonist;
serotonergic antagonist
1-ethyl-N-[[1-(phenylmethyl)-2-benzimidazolyl]methyl]-5-benzimidazolamine[no description available]low00benzimidazoles
dexlansoprazole[no description available]low00benzimidazoles;
sulfoxide
ag 14361[no description available]low00benzimidazoles
l 779976[no description available]low00benzimidazoles;
indoles;
piperidinecarboxamide;
primary amino compound;
secondary carboxamide		neuroprotective agent;
somatostatin receptor agonist
NNC 55-0396 (free base)[no description available]low00benzimidazoles;
cyclopropanecarboxylate ester;
organofluorine compound;
tertiary amino compound;
tetralins		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
neuroprotective agent;
potassium channel blocker;
T-type calcium channel blocker
azd 6244[no description available]low00benzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monochlorobenzenes;
organofluorine compound;
secondary amino compound		anticoronaviral agent;
antineoplastic agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
binimetinib[no description available]low00benzimidazoles;
bromobenzenes;
hydroxamic acid ester;
monofluorobenzenes;
secondary amino compound		antineoplastic agent;
apoptosis inducer;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
crenolanib[no description available]low00aminopiperidine;
aromatic ether;
benzimidazoles;
oxetanes;
quinolines;
tertiary amino compound		angiogenesis inhibitor;
antineoplastic agent;
apoptosis inducer;
EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor
jnj 10191584[no description available]low00benzimidazoles
5-(5,6-dimethoxy-1-benzimidazolyl)-3-[(2-methylsulfonylphenyl)methoxy]-2-thiophenecarbonitrile[no description available]low00benzimidazoles
zstk474[no description available]low00benzimidazoles;
morpholines;
organofluorine compound;
triamino-1,3,5-triazine		antineoplastic agent;
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
veliparib[no description available]low00benzimidazolesEC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor
N-[(1S)-1-(1H-benzimidazol-2-yl)-3-(methylthio)propyl]-2-(4-chlorophenoxy)-2-methylpropanamide[no description available]low00benzimidazoles
5-[[3-bromo-4-[(2-fluorophenyl)methoxy]-5-methoxyphenyl]methylamino]-1,3-dihydrobenzimidazol-2-one[no description available]low00benzimidazoles
(2S,4R)-N-(1H-benzimidazol-2-ylmethyl)-4-cyclohexyl-2-[[4-(hydroxymethyl)phenyl]methoxy]-3,4-dihydro-2H-pyran-6-carboxamide[no description available]low00benzimidazoles
5-fluoro-2-indolyldeschlorohalopemide[no description available]low00benzimidazoles
LSM-33057[no description available]low00benzimidazoles
4-(4-chloro-3-nitrophenyl)-N-[2-(5,6-dichloro-1-propyl-2-benzimidazolyl)ethyl]-2-thiazolamine[no description available]low00benzimidazoles
1-butyl-2-(2-methylphenyl)-7-propan-2-yl-5H-imidazo[4,5-g]quinoxalin-6-one[no description available]low00benzimidazoles
N-[4-(1H-benzimidazol-2-yl)phenyl]-1-[(5-methyl-1H-pyrazol-3-yl)methyl]-3-piperidinecarboxamide[no description available]low00benzimidazoles
4-[(6-chloro-1H-benzimidazol-2-yl)amino]benzoic acid[no description available]low00benzimidazoles
glasdegib[no description available]low00benzimidazoles;
nitrile;
phenylureas;
piperidines		antineoplastic agent;
Hedgehog signaling pathway inhibitor;
SMO receptor antagonist
1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[(1R)-2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]-3-pyridinecarboxamide[no description available]low00benzimidazoles
ML240[no description available]low00aromatic amine;
aromatic ether;
benzimidazoles;
primary amino compound;
quinazolines;
secondary amino compound		antineoplastic agent
brd4770[no description available]low00benzimidazoles
AZ3451[no description available]low00benzimidazoles;
benzodioxoles;
nitrile;
organobromine compound;
secondary carboxamide		anti-inflammatory agent;
autophagy inducer;
PAR2 negative allosteric modulator
tak 491[no description available]low001,2,4-oxadiazole;
aromatic ether;
benzimidazoles;
carboxylic ester;
cyclic carbonate ester;
dioxolane		angiotensin receptor antagonist;
antihypertensive agent;
prodrug
N-[4-(6-chloro-5-nitro-1H-benzimidazol-2-yl)phenyl]acetamide[no description available]low00benzimidazoles
ConditionIndicatedRelationship StrengthStudiesTrials
Breast Cancer0low10
Breast Carcinoma0low10
Breast Neoplasms0low10
Breast Tumors0low10
Cancer of Breast0low10
Cancer of the Breast0low10
Human Mammary Carcinoma0low10
Inflammation0low10
Innate Inflammatory Response0low10
Malignant Neoplasm of Breast0low10
Malignant Tumor of Breast0low10
Mammary Cancer0low10
Mammary Carcinoma, Human0low10
Mammary Neoplasm, Human0low10
Mammary Neoplasms, Human0low10
Neoplasms, Breast0low10
Tumors, Breast0low10